|
KMID : 0617320010100010128
|
|
Journal of Pharmacetical Sceiences Ewha Womans University
2001 Volume.10 No. 1 p.128 ~ p.131
|
|
|
Induction of Quinone Reductase Activity by Stilbene Analogs in Mouse Hepa 1c1c7 Cells
|
|
Heo, Yoen Hoi
Kim, Sanghee/Park, Jae Eun/Jeong, Lak Shin/Lee, Sang Kook
|
|
|
Abstract
|
|
|
|
Based on the potential cancer chemopreventive activity of resveratrol, a trihydroxystilbene with the induction of quinone reductase activity, this study was designed to determine if stilbene-related compounds were inducers of phaseⅡdetoxifying metabolic enzyme quinone reductase(QR) in the mouse hepatoma Hepa 1c1c7 cells. Among the thirteen compounds tested, several compounds including 3,4,5,3´,5´-pentamethoxy-trans-stilbene were found to potentially induce QR activity in this cell line. In addition, substitution with 3-thiofurane ring instead of phenyl ring in the stilbene skeleton also exhibited potential induction of QR activity. This result will give primary information to design the potential inducers of QR actvity in the stilbene analogs.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|